Structure of PDB 1ltk Chain A Binding Site BS01
Receptor Information
>1ltk Chain A (length=417) Species:
5833
(Plasmodium falciparum) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
HHHLGNKLSISDLKDIKNKKVLVRVDFNVPIENGIIKDTNRITATLPTIN
HLKKEGASKIILISHCGRPDGLRNEKYTLKPVAETLKGLLGEEVLFLNDC
VGKEVEDKINAAKENSVILLENLRFHIEEEGKGVDANGNKVKANKEDVEK
FQNDLTKLADVFINDAFGTAHRAHSSMVGVKLNVKASGFLMKKELEYFSK
ALENPQRPLLAILGGAKVSDKIQLIKNLLDKVDRMIIGGGMAYTFKKVLN
NMKIGTSLFDEAGSKIVGEIMEKAKAKNVQIFLPVDFKIADNFDNNANTK
FVTDEEGIPDNWMGLDAGPKSIENYKDVILTSKTVIWNGPQGVFEMPNFA
KGSIECLNLVVEVTKKGAITIVGGGDTASLVEQQNKKNEISHVSTGGGAS
LELLEGKELPGVLALSN
Ligand information
Ligand ID
AMP
InChI
InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKey
UDMBCSSLTHHNCD-KQYNXXCUSA-N
SMILES
Software
SMILES
CACTVS 3.370
Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(O)=O)[CH](O)[CH]3O
CACTVS 3.370
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.7.6
c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N
ACDLabs 12.01
O=P(O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.7.6
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)O)O)O)N
Formula
C10 H14 N5 O7 P
Name
ADENOSINE MONOPHOSPHATE
ChEMBL
CHEMBL752
DrugBank
DB00131
ZINC
ZINC000003860156
PDB chain
1ltk Chain A Residue 501 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1ltk
CRYSTAL STRUCTURE OF PHOSPHOGLYCERATE KINASE FROM PLASMODIUM FALCIPARUM
Resolution
3.0 Å
Binding residue
(original residue number in PDB)
G213 A214 K215 G340 V341 D374
Binding residue
(residue number reindexed from 1)
G215 A216 K217 G342 V343 D376
Annotation score
4
Enzymatic activity
Catalytic site (original residue number in PDB)
R39 K215 G373 G396
Catalytic site (residue number reindexed from 1)
R41 K217 G375 G398
Enzyme Commision number
2.7.2.3
: phosphoglycerate kinase.
Gene Ontology
Molecular Function
GO:0004618
phosphoglycerate kinase activity
GO:0005524
ATP binding
GO:0016301
kinase activity
GO:0043531
ADP binding
Biological Process
GO:0006094
gluconeogenesis
GO:0006096
glycolytic process
GO:0016310
phosphorylation
Cellular Component
GO:0005829
cytosol
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1ltk
,
PDBe:1ltk
,
PDBj:1ltk
PDBsum
1ltk
PubMed
UniProt
P27362
|PGK_PLAF7 Phosphoglycerate kinase (Gene Name=PGK)
[
Back to BioLiP
]