Structure of PDB 1lst Chain A Binding Site BS01

Receptor Information
>1lst Chain A (length=238) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALPQTVRIGTDTTYAPFSSKDAKGEFIGFDIDLGNEMCKRMQVKCTWVAS
DFDALIPSLKAKKIDAIISSLSITDKRQQEIAFSDKLYAADSRLIAAKGS
PIQPTLESLKGKHVGVLQGSTQEAYANDNWRTKGVDVVAYANQDLIYSDL
TAGRLDAALQDEVAASEGFLKQPAGKEYAFAGPSVKDKKYFGDGTGVGLR
KDDTELKAAFDKALTELRQDGTYDKMAKKYFDFNVYGD
Ligand information
Ligand IDLYS
InChIInChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKeyKDXKERNSBIXSRK-YFKPBYRVSA-O
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCCC[NH3+])C(O)=O
ACDLabs 10.04O=C(O)C(N)CCCC[NH3+]
OpenEye OEToolkits 1.5.0C(CC[NH3+])C[C@@H](C(=O)O)N
CACTVS 3.341N[C@@H](CCCC[NH3+])C(O)=O
OpenEye OEToolkits 1.5.0C(CC[NH3+])CC(C(=O)O)N
FormulaC6 H15 N2 O2
NameLYSINE
ChEMBL
DrugBank
ZINC
PDB chain1lst Chain A Residue 240 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1lst Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		Y14 F52 S70 S72 R77 L117 S120 T121 Q122 D161
Binding residue
(residue number reindexed from 1)		Y14 F52 S70 S72 R77 L117 S120 T121 Q122 D161
Annotation score4
Binding affinityPDBbind-CN: -logKd/Ki=7.85,Kd=14nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006865 amino acid transport
GO:0071705 nitrogen compound transport
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1lst, PDBe:1lst, PDBj:1lst
PDBsum1lst
PubMed8496186
UniProtP02911|ARGT_SALTY Lysine/arginine/ornithine-binding periplasmic protein (Gene Name=argT)

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