Structure of PDB 1ls5 Chain A Binding Site BS01

Receptor Information
>1ls5 Chain A (length=328) Species: 5833 (Plasmodium falciparum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SENDSIELDDVANLMFYGEGQIGTNKQPFMFIFDTGSANLWVPSVNCDSI
GCSTKHLYDASASKSYEKDGTKVEISYGSGTVRGYFSKDVISLGDLSLPY
KFIEVTDADDLEPIYSGSEFDGILGLGWKDLSIGSIDPVVVELKKQNKID
NALFTFYLPVHDKHVGYLTIGGIESDFYEGPLTYEKLNHDLYWQIDLDIH
FGKYVMQKANAVVDSGTSTITAPTSFLNKFFRDMNVIKVPFLPLYVTTCD
NDDLPTLEFHSRNNKYTLEPEFYMDPLSDIDPALCMLYILPVDIDDNTFI
LGDPFMRKYFTVFDYEKESVGFAVAKNL
Ligand information
>1ls5 Chain C (length=6) Species: 285516 (Streptomyces argenteolus subsp. toyonakensis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VVVLAL
Receptor-Ligand Complex Structure
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PDB1ls5 Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D34 G36 S76 Y77 G78 S79 I123 Y192 D214 G216 T217 S218 I294
Binding residue
(residue number reindexed from 1)		D34 G36 S76 Y77 G78 S79 I123 Y192 D214 G216 T217 S218 I294
Enzymatic activity
Catalytic site (original residue number in PDB) D34 S37 N39 W41 Y77 D214 T217
Catalytic site (residue number reindexed from 1) D34 S37 N39 W41 Y77 D214 T217
Enzyme Commision number 3.4.23.39: plasmepsin II.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ls5, PDBe:1ls5, PDBj:1ls5
PDBsum1ls5
PubMed12614616
UniProtQ8IM16|PLM4_PLAF7 Plasmepsin IV (Gene Name=PMIV)

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