Structure of PDB 1lry Chain A Binding Site BS01

Receptor Information

>1lry Chain A (length=165) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AILNILEFPDPRLRTIAKPVEVVDDAVRQLIDDMFETMYEAPGIGLAATQ
VNVHKRIVVMDLSEDKSEPRVFINPEFEPLTEDMDQYQEGCLSVPGFYEN
VDRPQKVRIKALDRDGNPFEEVAEGLLAVCIQHECDHLNGKLFVDYLSTL
KRDRIRKKLEKQHRQ

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1lry Chain A Residue 168 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1lry The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	C91 H133 H137
Binding residue (residue number reindexed from 1)	C91 H133 H137
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	G45 Q50 C91 L92 H133 E134 H137
Catalytic site (residue number reindexed from 1)	G45 Q50 C91 L92 H133 E134 H137
Enzyme Commision number	3.5.1.88: peptide deformylase.

Gene Ontology

	Molecular Function
GO:0016787	hydrolase activity
GO:0042586	peptide deformylase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006412	translation
GO:0043686	co-translational protein modification

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Biological Process

External links

PDB	RCSB:1lry, PDBe:1lry, PDBj:1lry
PDBsum	1lry
PubMed	12126617
UniProt	Q9I7A8\|DEF_PSEAE Peptide deformylase (Gene Name=def)

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