Structure of PDB 1lpq Chain A Binding Site BS01

Receptor Information
>1lpq Chain A (length=557) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSP
KAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCD
FTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIA
NFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKW
KEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLK
KCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADT
VGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNL
QLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQ
LKELTAPDENIPAKILSYNRANRAVAILCNHQEKSMMNLQTKIDAKKEQL
ADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDR
EENKQIALGTSKLNFLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDM
ADEDYEF
Ligand information
Receptor-Ligand Complex Structure
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PDB1lpq 8-Oxoguanine rearranges the active site of human topoisomerase I
Resolution3.14 Å
Binding residue
(original residue number in PDB)		R364 V410 T411 W412 Y426 K436 K439 K443 K587 H632 Q633 T718 N722
Binding residue
(residue number reindexed from 1)		R163 V209 T210 W211 Y225 K235 K238 K242 K386 H431 Q432 T510 N514
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1lpq, PDBe:1lpq, PDBj:1lpq
PDBsum1lpq
PubMed12209008
UniProtP11387|TOP1_HUMAN DNA topoisomerase 1 (Gene Name=TOP1)

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