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Receptor Information

>1ln1 Chain A (length=203) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

FSEEQFWEACAELQQPALAGADWQLLVETSGISIYRLLDKKTGLYEYKVF
GVLEDCSPTLLADIYMDSDYRKQWDQYVKELYEQECNGETVVYWEVKYPF
PMSNRDYVYLRQRRDLDMEGRKIHVILARSTSMPQLGERSGVIRVKQYKQ
SLAIESDGKKGSKVFMYYFDNPGGQIPSWLINWAAKNGVPNFLKDMARAC
QNY

Ligand ID

DLP

InChI

InChI=1S/C44H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h14-17,20-23,42H,6-13,18-19,24-41H2,1-5H3/b16-14-,17-15-,22-20-,23-21-/t42-/m1/s1

InChIKey

FVXDQWZBHIXIEJ-LNDKUQBDSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@H](CO[P@@](=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC
CACTVS 3.341	CCCCCC=CCC=CCCCCCCCC(=O)OC[CH](CO[P]([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCC=CCCCCC
ACDLabs 10.04	O=C(OCC(OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COP([O-])(=O)OCC[N+](C)(C)C)CCCCCCC\C=C/C\C=C/CCCCC
OpenEye OEToolkits 1.5.0	CCCCCC=CCC=CCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCC=CCCCCC
CACTVS 3.341	CCCCC/C=C\C\C=C/CCCCCCCC(=O)OC[C@H](CO[P]([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C/C=C\CCCCC

Formula

C44 H80 N O8 P

Name

1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE;
DI-LINOLEOYL-3-SN-PHOSPHATIDYLCHOLINE

PDB chain

1ln1 Chain A Residue 2313 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1ln1 Structure of human phosphatidylcholine transfer protein in complex with its ligand.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	L33 V34 I41 Y54 V56 Y72 R78 Y84 W101 V103 Y114 Y155 Q157 L159 V171 M173 Y175 V196 F199 L200
Binding residue (residue number reindexed from 1)	L26 V27 I34 Y47 V49 Y65 R71 Y77 W94 V96 Y107 Y148 Q150 L152 V164 M166 Y168 V189 F192 L193
Annotation score	1

Enzyme Commision number

	Molecular Function
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0008525	phosphatidylcholine transporter activity
GO:0031210	phosphatidylcholine binding

	Biological Process
GO:0006869	lipid transport
GO:0015914	phospholipid transport
GO:0120163	negative regulation of cold-induced thermogenesis

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

PDB	RCSB:1ln1, PDBe:1ln1, PDBj:1ln1
PDBsum	1ln1
PubMed	12055623
UniProt	Q9UKL6\|PPCT_HUMAN Phosphatidylcholine transfer protein (Gene Name=PCTP)

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Structure of PDB 1ln1 Chain A Binding Site BS01