Structure of PDB 1lka Chain A Binding Site BS01
Receptor Information
>1lka Chain A (length=240) Species:
9823
(Sus scrofa) [
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VVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTLIRQNWVMTAAHCVDRE
LTFRVVVGEHNLNQNDGTEQYVGVQKIVVHPYWNTDDVAAGYDIALLRLA
QSVTLNSYVQLGVLPRAGTILANNSPCYITGWGLTRTNGQLAQTLQQAYL
PTVDYAICSSSSYWGSTVKNSMVCAGGDGVRSGCQGDSGGPLHCLVNGQY
AVHGVTSFVSRLGCNVTRKPTVFTRVSAYISWINNVIASN
Ligand information
Ligand ID
CA
InChI
InChI=1S/Ca/q+2
InChIKey
BHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Ca+2]
Formula
Ca
Name
CALCIUM ION
ChEMBL
DrugBank
DB14577
ZINC
PDB chain
1lka Chain A Residue 401 [
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Receptor-Ligand Complex Structure
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PDB
1lka
Metal binding to porcine pancreatic elastase: calcium or not calcium.
Resolution
1.7 Å
Binding residue
(original residue number in PDB)
E59 N61 Q64 D66 E69
Binding residue
(residue number reindexed from 1)
E59 N61 Q64 D66 E69
Annotation score
4
Enzymatic activity
Catalytic site (original residue number in PDB)
H45 D93 Q185 G186 D187 S188 G189
Catalytic site (residue number reindexed from 1)
H45 D93 Q185 G186 D187 S188 G189
Enzyme Commision number
3.4.21.36
: pancreatic elastase.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005515
protein binding
GO:0008236
serine-type peptidase activity
GO:0046872
metal ion binding
Biological Process
GO:0006508
proteolysis
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1lka
,
PDBe:1lka
,
PDBj:1lka
PDBsum
1lka
PubMed
12198296
UniProt
P00772
|CELA1_PIG Chymotrypsin-like elastase family member 1 (Gene Name=CELA1)
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