Structure of PDB 1lei Chain A Binding Site BS01

Receptor Information

>1lei Chain A (length=273) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTG
PGTVRISLVTKDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGI
QCVKKRDLEQAISQRIQTNNNPFHVPIEEQRGDYDLNAVRLCFQVTVRDP
AGRPLLLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDK
VQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRV
SMQLRRPSDRELSEPMEFQYLPD

Ligand information

>1lei Chain C (length=17) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ctcagggaaagtacaga

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1lei The kB DNA sequence from the HIV Long Terminal Repeat functions as an allosteric regulator of HIV transcription
Resolution	2.7 Å
Binding residue (original residue number in PDB)	Y36 C38 E39 K122 K123 Q220 R246 Q247
Binding residue (residue number reindexed from 1)	Y18 C20 E21 K104 K105 Q202 R228 Q229
Binding affinity	PDBbind-CN: Kd=0.8nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:1lei, PDBe:1lei, PDBj:1lei
PDBsum	1lei
PubMed	11970949
UniProt	Q04207\|TF65_MOUSE Transcription factor p65 (Gene Name=Rela)

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