Structure of PDB 1lba Chain A Binding Site BS01

Receptor Information
>1lba Chain A (length=146) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKQRESTDAIFVHCSATKPSQNVGVREIRQWHKEQGWLDVGYHFIIKRDG
TVEAGRDEMAVGSHAKGYNHNSIGVCLVGGIDDKGKFDANFTPAQMQSLR
SLLVTLLAKYEGAVLRAHHEVAPKACPSFDLKRWWEKNELVTSDRG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1lba Chain A Residue 151 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1lba The structure of bacteriophage T7 lysozyme, a zinc amidase and an inhibitor of T7 RNA polymerase.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H17 H122 C130
Binding residue
(residue number reindexed from 1)		H13 H118 C126
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H17 Y46 H122 K128 C130
Catalytic site (residue number reindexed from 1) H13 Y42 H118 K124 C126
Enzyme Commision number 3.5.1.28: N-acetylmuramoyl-L-alanine amidase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0009253 peptidoglycan catabolic process
GO:0031640 killing of cells of another organism
GO:0032897 negative regulation of viral transcription
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1lba, PDBe:1lba, PDBj:1lba
PDBsum1lba
PubMed8171031
UniProtP00806|ENLYS_BPT7 Endolysin (Gene Name=3.5)

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