Structure of PDB 1lb8 Chain A Binding Site BS01

Receptor Information
>1lb8 Chain A (length=261) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKY
KLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVID
FSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK
IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIE
QRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLK
NKWWYDKGECG
Ligand information
Ligand IDAMQ
InChIInChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
InChIKeyUUDAMDVQRQNNHZ-YFKPBYRVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0Cc1c(c(no1)O)C[C@@H](C(=O)O)N
OpenEye OEToolkits 1.5.0Cc1c(c(no1)O)CC(C(=O)O)N
CACTVS 3.341Cc1onc(O)c1C[CH](N)C(O)=O
CACTVS 3.341Cc1onc(O)c1C[C@H](N)C(O)=O
ACDLabs 10.04O=C(O)C(N)Cc1c(onc1O)C
FormulaC7 H10 N2 O4
Name(S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID;
AMPA
ChEMBLCHEMBL276815
DrugBankDB02057
ZINCZINC000002047472
PDB chain1lb8 Chain A Residue 427 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1lb8 Mechanism of glutamate receptor desensitization.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		Y61 T91 R96 G141 S142 T143 E193
Binding residue
(residue number reindexed from 1)		Y60 T90 R95 G140 S141 T142 E192
Annotation score1
Binding affinityBindingDB: Ki=17nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1lb8, PDBe:1lb8, PDBj:1lb8
PDBsum1lb8
PubMed12015593
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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