Structure of PDB 1la3 Chain A Binding Site BS01

Receptor Information

>1la3 Chain A (length=188) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GNSKSGALSKEILEELQLNTKFTEEELSSWYQSFLKECPSGRITRQEFQT
IYSKFFPEADPKAYAQHVFRSFDANSDGTLDFKQYVIALHMTSAGKTNQK
LEWAFSLYDVDGNGTISKNEVLEIVTAIFKMISPEDTKHLPEDENTPEKR
AEKIWGFFGKKDDDKLTEKEFIEGTLANKEILRLIQFE

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

1la3 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1la3 Structure and calcium-binding studies of a recoverin mutant (E85Q) in an allosteric intermediate state.
Resolution	N/A
Binding residue (original residue number in PDB)	D110 D112 N114 T116 E121
Binding residue (residue number reindexed from 1)	D109 D111 N113 T115 E120
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0051924	regulation of calcium ion transport

	Cellular Component
GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005829	cytosol
GO:0016020	membrane
GO:0042995	cell projection
GO:0043204	perikaryon

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Cellular Component

External links

PDB	RCSB:1la3, PDBe:1la3, PDBj:1la3
PDBsum	1la3
PubMed	11980481
UniProt	P21457\|RECO_BOVIN Recoverin (Gene Name=RCVRN)

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