Structure of PDB 1l83 Chain A Binding Site BS01

Receptor Information
>1l83 Chain A (length=162) Species: 10665 (Tequatrovirus T4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAI
GRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAAAI
NMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVI
TTFRTGTWDAYK
Ligand information
Ligand IDBNZ
InChIInChI=1S/C6H6/c1-2-4-6-5-3-1/h1-6H
InChIKeyUHOVQNZJYSORNB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 11.02
CACTVS 3.352
OpenEye OEToolkits 1.7.0		c1ccccc1
FormulaC6 H6
NameBENZENE
ChEMBLCHEMBL277500
DrugBank
ZINCZINC000000967532
PDB chain1l83 Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1l83 A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		V87 A99 V111 L118
Binding residue
(residue number reindexed from 1)		V87 A99 V111 L118
Annotation score1
Binding affinityMOAD: Kd=0.4mM
PDBbind-CN: -logKd/Ki=3.40,Kd=0.40mM
Enzymatic activity
Catalytic site (original residue number in PDB) E11 D20
Catalytic site (residue number reindexed from 1) E11 D20
Enzyme Commision number 3.2.1.17: lysozyme.
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1l83, PDBe:1l83, PDBj:1l83
PDBsum1l83
PubMed1731252
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E)

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