Structure of PDB 1l2o Chain A Binding Site BS01

Receptor Information
>1l2o Chain A (length=777) Species: 31199 (Argopecten irradians) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FSDPDFQYLAVDRKKLMKAFDGKKNCWVPDEKEGFASAEIQSSKGDEITV
KIVADSSTRTVKKDDIQSMNPPKFEKLEDMANMTYLNEASVLYNLRSRYT
SGLIYTYSGLFCIAVNPYRRLPIYTDSVIAKYRGKRKTEIPPHLFSVADN
AYQNMVTDRENQSCLITGESGAGKTENTKKVIMYLAKVACAVKEGSLEDQ
IIQANPVLEAYGNAKTTRNNNSSRFGKFIRIHFGPTGKIAGADIETYLLE
KSRVTYQQSAERNYHIFYQICSNAIPELNDVMLVTPDSGLYSFINQGCLT
VDNIDDVEEFKLCDEAFDILGFTKEEKQSMFKCTASILHMGEMKFQAESD
GTAEAEKVAFLCGINAGDLLKALLKPKVTEMVTKGQNMNQVVNSVGALAK
SLYDRMFNWLVRRVNKTLDTKAKRNYYIGVLDIAGFEIFDFNSFEQLCIN
YTNERLQQFFNHHMFILEQEEYKKEGIAWEFIDFGMDLQMCIDLIEKPMG
ILSILEEECMFPKADDKSFQDKLYQNHMGKNRMFTKPGKRPNQGPAHFEL
HHYAGNVPYSITGWLEKNKDPINENVVALLGASKEPLVAELFKAFQTISA
VHRESLNKLMKNLYSTHPHFVRCIIPNELKQPGLVDAELVLHQLQCNGVL
RKGFPSRLIYSEFKQRYSILAPNAIDGKTVSEKILAGLQMDPAEYRLGTT
KVFFKAGVLGNLEEMRDERLSKIISMFQAHIRGYLIRKAYKKLQDQRIGL
SVIQRNIRKWLVLRNWQWWKLYSKVKP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1l2o Chain A Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1l2o Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		T183 S241
Binding residue
(residue number reindexed from 1)		T175 S223
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) S178 G179 T183 N237 S240 S241 G463 E465
Catalytic site (residue number reindexed from 1) S170 G171 T175 N219 S222 S223 G435 E437
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1l2o, PDBe:1l2o, PDBj:1l2o
PDBsum1l2o
PubMed12297624
UniProtP24733|MYS_ARGIR Myosin heavy chain, striated muscle

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