Structure of PDB 1kvk Chain A Binding Site BS01

Receptor Information
>1kvk Chain A (length=378) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVS
LNLPNVGIKQVWDVATLQLLDTEKLKKVAGLPRDCVGNEGLSLLAFLYLY
LAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTN
PLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRY
QQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLIKFPEIMAPLLT
SIDAISLECERVLGEMAAAPVPEQYLVLEELMDMNQHHLNALGVGHASLD
QLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQALTGCGFD
CWETSIGAPGVSMHSATSIEDPVRQALG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1kvk Chain A Residue 536 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1kvk The Structure of a Binary complex between a Mammalian Mevalonate Kinase and ATP: Insights into the Reaction Mechanism and Human Inherited Disease
Resolution2.4 Å
Binding residue
(original residue number in PDB)		G144 S146 A147 E193 H197 D204
Binding residue
(residue number reindexed from 1)		G128 S130 A131 E177 H181 D188
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.1.36: mevalonate kinase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003729 mRNA binding
GO:0004496 mevalonate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006720 isoprenoid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0016125 sterol metabolic process
GO:0016310 phosphorylation
GO:0017148 negative regulation of translation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0045540 regulation of cholesterol biosynthetic process
GO:0050728 negative regulation of inflammatory response
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1kvk, PDBe:1kvk, PDBj:1kvk
PDBsum1kvk
PubMed11877411
UniProtP17256|KIME_RAT Mevalonate kinase (Gene Name=Mvk)

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