Structure of PDB 1ksi Chain A Binding Site BS01

Receptor Information
>1ksi Chain A (length=642) Species: 3888 (Pisum sativum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQHPLDPLTKEEFLAVQTIVQNKYPISNNRLAFHYIGLDDPEKDHVLRYE
THPTLVSIPRKIFVVAIINSQTHEILINLRIRSIVSDNIHNGYGFPILSV
DEQSLAIKLPLKYPPFIDSVKKRGLNLSEIVCSSFTMGWFGEEKNVRTVR
LDCFMKESTVNIYVRPITGITIVADLDLMKIVEYHDRDIEAVPTAENTEY
QVSKQSPPFGPKQHSLTSHQPQGPGFQINGHSVSWANWKFHIGFDVRAGI
VISLASIYDLEKHKSRRVLYKGYISELFVPYQDPTEEFYFKTFFDSGEFG
FGLSTVSLIPNRDCPPHAQFIDTYVHSANGTPILLKNAICVFEQYGNIMW
RHTENGIPNESIEESRTEVNLIVRTIVTVGNYDNVIDWEFKASGSIKPSI
ALSGILEIKGTNIKHKDEIKEDLHGKLVSANSIGIYHDHFYIYYLDFDID
GTHNSFEKTSLKTVRIKDGSSKRKSYWTTETQTAKTESDAKITIGLAPAE
LVVVNPNIKTAVGNEVGYRLIPAIPAHPLLTEDDYPQIRGAFTNYNVWVT
AYNRTEKWAGGLYVDHSRGDDTLAVWTKQNREIVNKDIVMWHVVGIHHVP
AQEDFPIMPLLSTSFELRPTNFFERNPVLKTLSPRDVAWPGC
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain1ksi Chain A Residue 650 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1ksi Crystal structure of a eukaryotic (pea seedling) copper-containing amine oxidase at 2.2 A resolution.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H442 H444 H603
Binding residue
(residue number reindexed from 1)		H437 H439 H598
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y286 D300 Y387 H442 H444 H603
Catalytic site (residue number reindexed from 1) Y281 D295 Y382 H437 H439 H598
Enzyme Commision number 1.4.3.21: primary-amine oxidase.
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0008131 primary methylamine oxidase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0048038 quinone binding
GO:0052595 aliphatic amine oxidase activity
GO:0052597 diamine oxidase activity
Biological Process
GO:0009308 amine metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1ksi, PDBe:1ksi, PDBj:1ksi
PDBsum1ksi
PubMed8805580
UniProtQ43077|AMO_PEA Primary amine oxidase

[Back to BioLiP]