Structure of PDB 1kpl Chain A Binding Site BS01

Receptor Information
>1kpl Chain A (length=430) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPLAILFMAAVVGTLTGLVGVAFEKAVSWVQNMRIGALVQVADHAFLLWP
LAFILSALLAMVGYFLVRKFAPEAGGSGIPEIEGALEELRPVRWWRVLPV
KFIGGMGTLGAGMVLGREGPTVQIGGNLGRMVLDVFRMRSAEARHTLLAT
GAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFR
IFNGEAPIIEVGKLSDAPVNTLWLYLILGIIFGVVGPVFNSLVLRTQDMF
QRFHGGEIKKWVLMGGAIGGLCGILGLIEPAAAGGGFNLIPIAAAGNFSV
GLLLFIFITRVVTTLLCFSSGAPGGIFAPMLALGTLLGTAFGMAAAVLFP
QYHLEAGTFAIAGMGALMAASVRAPLTGIVLVLEMTDNYQLILPMIITCL
GATLLAQFLGGKPLYSTILARTLAKQDAEQ
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain1kpl Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1kpl X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		S107 F357
Binding residue
(residue number reindexed from 1)		S77 F327
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
GO:0015108 chloride transmembrane transporter activity
GO:0015297 antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1kpl, PDBe:1kpl, PDBj:1kpl
PDBsum1kpl
PubMed11796999
UniProtQ8ZRP8|CLCA_SALTY H(+)/Cl(-) exchange transporter ClcA (Gene Name=clcA)

[Back to BioLiP]