Structure of PDB 1ko7 Chain A Binding Site BS01

Receptor Information
>1ko7 Chain A (length=285) Species: 1288 (Staphylococcus xylosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLTTKSLVERFELEMIAGEAGLNKQIKNTDISRPGLEMAGYFSHYASDRI
QLLGTTELSFYNLLPDEERKGRMRKLCRPETPAIIVTRDLEPPEELIEAA
KEHETPLITSKIATTQLMSRLTTFLEHELARTTSLHGVLVDVYGVGVLIT
GDSGIGKSETALELIKRGHRLVADDNVEIREISKDELIGRAPKLIEHLLE
IRGLGIINVMTLFGAGSILTEKRLRLNIHLENEETLRILDTEITKKTIPV
RPGRNVAVIIEVAAMNYRLNIMGINTAEEFNDRLN
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain1ko7 Chain A Residue 315 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1ko7 Structure of the full-length HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution: Mimicking the product/substrate of the phospho transfer reactions.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		R33 T55 T56 R88 T114
Binding residue
(residue number reindexed from 1)		R33 T55 T56 R88 T114
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.-
2.7.4.-
Gene Ontology
Molecular Function
GO:0000155 phosphorelay sensor kinase activity
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0006109 regulation of carbohydrate metabolic process
GO:0016310 phosphorylation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ko7, PDBe:1ko7, PDBj:1ko7
PDBsum1ko7
PubMed11904409
UniProtQ9S1H5|HPRK_STAXY HPr kinase/phosphorylase (Gene Name=hprK)

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