Structure of PDB 1kln Chain A Binding Site BS01

Receptor Information
>1kln Chain A (length=595) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VISYDNYVTILDEETLKAWIAKLEKAPVFAFATETDSLDNISANLVGLSF
AIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKY
DRGILANYGIELRGIAFDTMLESYILNSVAGRHDMDSLAERWLKHKTITF
EEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQKHKGPL
NVFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEI
AGEEFNLSSQLQTILFEKQGIKPLKTSEEVLEELALDYPLPKVILEYRGL
AKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRN
EEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDI
HRATAAEVFGLPLETVTSEQRRSAKAINFGLIYGMSAFGLARQLNIPRKE
AQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYLPDIKSSNG
ARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDE
LVFEVHKDDVDAVAKQIHQLMENCTRLDVPLLVEVGSGENWDQAH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1kln Structure of DNA polymerase I Klenow fragment bound to duplex DNA.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E357 T358 L361 Q419 N420 K422 Y423 M443 R455 D457 F473 Y497 T609 S610 R631 K635 Y659 H660 V663 T672
Binding residue
(residue number reindexed from 1)		E34 T35 L38 Q96 N97 K99 Y100 M120 R132 D134 F150 Y174 T276 S277 R298 K302 Y326 H327 V330 T339
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:1kln, PDBe:1kln, PDBj:1kln
PDBsum1kln
PubMed8469987
UniProtP00582|DPO1_ECOLI DNA polymerase I (Gene Name=polA)

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