Structure of PDB 1kl9 Chain A Binding Site BS01

Receptor Information
>1kl9 Chain A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELRI
GRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHV
AEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDS
LDLNEDEREVLINNINRR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1kl9 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1kl9 Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha
Resolution1.9 Å
Binding residue
(original residue number in PDB)		H154 D158
Binding residue
(residue number reindexed from 1)		H140 D144
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity

View graph for
Molecular Function
External links
PDB RCSB:1kl9, PDBe:1kl9, PDBj:1kl9
PDBsum1kl9
PubMed11859078
UniProtP05198|IF2A_HUMAN Eukaryotic translation initiation factor 2 subunit 1 (Gene Name=EIF2S1)

[Back to BioLiP]