Structure of PDB 1kkq Chain A Binding Site BS01

Receptor Information

>1kkq Chain A (length=269) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCM
AEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFAN
LDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRK
PFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEK
MQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKK
TESDAALHPLLQEIYRDMY

Ligand information

>1kkq Chain E (length=19) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

NMGLEAIIRKALMGKYDQW

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1kkq Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
Resolution	3.0 Å
Binding residue (original residue number in PDB)	R209 E212 K216 E289 K292 V306 K310 Y314 Y464 Y468
Binding residue (residue number reindexed from 1)	R10 E13 K17 E90 K93 V107 K111 Y115 Y265 Y269

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:1kkq, PDBe:1kkq, PDBj:1kkq
PDBsum	1kkq
PubMed	11845213
UniProt	Q07869\|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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