Structure of PDB 1kix Chain A Binding Site BS01

Receptor Information

>1kix Chain A (length=446) Species: 200597 (Sterkiella nova)

YEYVELAKASLTSAQPQHFYAVVIDATFPYKTNQERYICSLKIVDPTLYL
KQQKGAGDASDYATLVLYAKRFEDLPIIHRAGDIIRVHRATLRLYNGQRQ
FNANVFYSSSWALFSTDKRSVTQEINNQDTTPFSFSSKHATIEKNEISIL
QNLRKWANQYFSSYSVISSDMYTALNKAQAQKGDFDVVAKILQVHELDEY
TNELKLKDASGQVFYTLSLKLKFPHVRTGEVVRIRSATYDETSTQKKVLI
LSHYSNIITFIQSSKLAKELRAKIQDDHSSLNAVVLTEVDKKHAALPSTS
LQDLFHHADSDKELQAQDTFRTQFYVTKIEPSDVKEWVKGYDRKTKKSSS
LKGASGKGDNIFQVQFLVKDASTQLNNNTYRVLLYTQDGLGANFFNVKAD
NLHKNADARKKLEDSAELLTKFNSYVDAVVERRNGFYLIKDTKLIY

Ligand information

>1kix Chain D (length=7)

tttgggg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1kix Dimeric structure of the Oxytricha nova telomere end-binding protein alpha-subunit bound to ssDNA.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): P51 Y65 T67 N68 R71 I73 S75 K77 Y103 R124 T126 R128 Y130 Q135 N137 N139 D223 D225 R274 S275 Y293
• Binding residue (residue number reindexed from 1): P16 Y30 T32 N33 R36 I38 S40 K42 Y68 R89 T91 R93 Y95 Q100 N102 N104 D184 D186 R235 S236 Y254

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0010521 telomerase inhibitor activity
• GO:0043047 single-stranded telomeric DNA binding
• GO:0098505 G-rich strand telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0016233 telomere capping
• GO:0032210 regulation of telomere maintenance via telomerase

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0000782 telomere cap complex
• GO:0000783 nuclear telomere cap complex
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1kix, PDBe:1kix, PDBj:1kix
• PDBsum: 1kix
• PubMed: 11836536
• UniProt: P29549|TEBA_STENO Telomere-binding protein subunit alpha (Gene Name=MAC-56A)