Structure of PDB 1kh8 Chain A Binding Site BS01

Receptor Information

>1kh8 Chain A (length=125) Species: 9913 (Bos taurus)

MKETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHE
SLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKT
TQANKHIIVACEGNGYVPVHFDASV

Ligand information

• Ligand ID: CS
• InChI: InChI=1S/Cs/q+1
• InChIKey: NCMHKCKGHRPLCM-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Cs+]
• Formula: Cs
• Name: CESIUM ION
• PDB chain: 1kh8 Chain A Residue 126

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1kh8 The crystal structure of the cis-proline to glycine variant (P114G) of ribonuclease A.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): C58 Y73 N113 G114 Y115
• Binding residue (residue number reindexed from 1): C59 Y74 N114 G115 Y116
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H12 K41 H119 F120 D121
• Catalytic site (residue number reindexed from 1): H13 K42 H120 F121 D122
• Enzyme Commision number: 4.6.1.18: pancreatic ribonuclease.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004519 endonuclease activity
• GO:0004522 ribonuclease A activity
• GO:0004540 RNA nuclease activity
• GO:0005515 protein binding
• GO:0016829 lyase activity

Biological Process

• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:1kh8, PDBe:1kh8, PDBj:1kh8
• PDBsum: 1kh8
• PubMed: 16199662
• UniProt: P61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)