Structure of PDB 1k7l Chain A Binding Site BS01

Receptor Information

>1k7l Chain A (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE
KTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLD
LNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPF
CDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQ
EGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTE
SDAALHPLLQEIYRDMY

Ligand information

>1k7l Chain B (length=13) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ERHKILHRLLQEG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1k7l Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	T288 K292 L302 L309 K310 P458 L459 E462
Binding residue (residue number reindexed from 1)	T87 K91 L101 L108 K109 P257 L258 E261

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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External links

PDB	RCSB:1k7l, PDBe:1k7l, PDBj:1k7l
PDBsum	1k7l
PubMed	11698662
UniProt	Q07869\|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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