Structure of PDB 1k4w Chain A Binding Site BS01

Receptor Information

>1k4w Chain A (length=244) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREA
LWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRM
CRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEE
EIALFSSAVLISPDRAWLLEPRKVQKLQEKIYFALQHVIQKNHLDDETLA
KLIAKIPTITAVCNLHGEKLQVFKQSHPDIVNTLFPPLYKELFN

Ligand information

>1k4w Chain B (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

HKILHRLLQE

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1k4w X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	K278 Q288 I292 P444 L445 E448
Binding residue (residue number reindexed from 1)	K71 Q81 I85 P237 L238 E241

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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External links

PDB	RCSB:1k4w, PDBe:1k4w, PDBj:1k4w
PDBsum	1k4w
PubMed	11689423
UniProt	P45446\|RORB_RAT Nuclear receptor ROR-beta (Gene Name=Rorb)

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