Structure of PDB 1k0a Chain A Binding Site BS01
Receptor Information
>1k0a Chain A (length=234) Species:
4932
(Saccharomyces cerevisiae) [
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SRITKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLG
EHRAPEFVSVNPNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNP
LLWSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQKIASAVERYT
DEVRRVYGVVEMALAERREALVMEFDYPVWLVGDKLTIADLAFVPWNNVV
DRIGINIKIEFPEVYKWTKHMMRRPAVIKALRGE
Ligand information
Ligand ID
GTX
InChI
InChI=1S/C16H29N3O6S/c1-2-3-4-5-8-26-10-12(15(23)18-9-14(21)22)19-13(20)7-6-11(17)16(24)25/h11-12H,2-10,17H2,1H3,(H,18,23)(H,19,20)(H,21,22)(H,24,25)/p+1/t11-,12-/m0/s1
InChIKey
HXJDWCWJDCOHDG-RYUDHWBXSA-O
SMILES
Software
SMILES
CACTVS 3.341
CCCCCCSC[CH](NC(=O)CC[CH]([NH3+])C(O)=O)C(=O)NCC(O)=O
CACTVS 3.341
CCCCCCSC[C@H](NC(=O)CC[C@H]([NH3+])C(O)=O)C(=O)NCC(O)=O
ACDLabs 10.04
O=C(O)CNC(=O)C(NC(=O)CCC(C(=O)O)[NH3+])CSCCCCCC
OpenEye OEToolkits 1.5.0
CCCCCCSCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)[NH3+]
OpenEye OEToolkits 1.5.0
CCCCCCSC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)[NH3+]
Formula
C16 H30 N3 O6 S
Name
S-HEXYLGLUTATHIONE
ChEMBL
DrugBank
ZINC
PDB chain
1k0a Chain A Residue 355 [
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Receptor-Ligand Complex Structure
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PDB
1k0a
Crystal structures of the yeast prion Ure2p functional region in complex with glutathione and related compounds.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
A122 P123 N124 F146 R164 V165 E180 S181 L231 W316
Binding residue
(residue number reindexed from 1)
A23 P24 N25 F47 R65 V66 E81 S82 L132 W196
Annotation score
2
Enzymatic activity
Catalytic site (original residue number in PDB)
A122
Catalytic site (residue number reindexed from 1)
A23
Enzyme Commision number
1.11.1.9
: glutathione peroxidase.
1.8.4.-
Gene Ontology
Molecular Function
GO:0003714
transcription corepressor activity
Biological Process
GO:0006808
regulation of nitrogen utilization
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:1k0a
,
PDBe:1k0a
,
PDBj:1k0a
PDBsum
1k0a
PubMed
11695904
UniProt
P23202
|URE2_YEAST Transcriptional regulator URE2 (Gene Name=URE2)
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