Structure of PDB 1jyr Chain A Binding Site BS01
Receptor Information
>1jyr Chain A (length=96) Species:
9606
(Homo sapiens) [
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GSMAWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDV
QHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDI
Ligand information
>1jyr Chain L (length=9) Species:
32630
(synthetic construct) [
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APSYVNVQN
Receptor-Ligand Complex Structure
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PDB
1jyr
Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
Resolution
1.55 Å
Binding residue
(original residue number in PDB)
R67 R86 S88 S90 S96 H107 F108 K109 L120 W121
Binding residue
(residue number reindexed from 1)
R12 R31 S33 S35 S41 H52 F53 K54 L65 W66
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:1jyr
,
PDBe:1jyr
,
PDBj:1jyr
PDBsum
1jyr
PubMed
11827484
UniProt
P62993
|GRB2_HUMAN Growth factor receptor-bound protein 2 (Gene Name=GRB2)
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