Structure of PDB 1jse Chain A Binding Site BS01

Receptor Information

>1jse Chain A (length=129) Species: 9103 (Meleagris gallopavo)

KVYGRCELAAAMKRLGLDNYRGYSLGNWVCAAKFESNFNTHATNRNTDGS
TDYGILQINSRWWCNDGRTPGSKNLCNIPCSALLSSDITASVNCAKKIAS
GGNGMNAWVAWRNRCKGTDVHAWIRGCRL

Ligand information

• Ligand ID: POL
• InChI: InChI=1S/C3H8O/c1-2-3-4/h4H,2-3H2,1H3
• InChIKey: BDERNNFJNOPAEC-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: CCCO
  ACDLabs 10.04: OCCC
• Formula: C3 H8 O
• Name: N-PROPANOL;
  1-PROPONOL
• ChEMBL: CHEMBL14687
• DrugBank: DB03175
• ZINC: ZINC000000895969
• PDB chain: 1jse Chain A Residue 130

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1jse Full-matrix least-squares refinement of lysozymes and analysis of anisotropic thermal motion.
• Resolution: 1.12 Å
• Binding residue (original residue number in PDB): S24 N27 V120 H121
• Binding residue (residue number reindexed from 1): S24 N27 V120 H121
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E35 N46 D48 S50 D52 N59
• Catalytic site (residue number reindexed from 1): E35 N46 D48 S50 D52 N59
• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0005539 glycosaminoglycan binding
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0042802 identical protein binding

Biological Process

• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm

External links

• PDB: RCSB:1jse, PDBe:1jse, PDBj:1jse
• PDBsum: 1jse
• PubMed: 9517539
• UniProt: P00703|LYSC_MELGA Lysozyme C (Gene Name=LYZ)