BioLiP

Receptor Information

>1jrr Chain A (length=357) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTE
DQMAKVLQFNKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEY
IRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVD
GDTRMVLVNAVYFKGKWKTPFEKKYPFRVNSAQRTPVQMMYLREKLNIGY
IEDLKAQILELPYAGDVSMFLLLPDDVSTGLELLESEITYDKLNKWTSKD
KMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERND
LFLSEVFHQAMVDVNEEGTTGRTGHGGPQFVADHPFLFLIMHKITNCILF
FGRFSSP

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	1jrr CRYSTAL STRUCTURE OF THE COMPLEX OF PLASMINOGEN ACTIVATOR INHIBITOR 2 WITH A PEPTIDE MIMICKING THE REACTIVE CENTER LOOP
Resolution	1.6 Å
Binding residue (original residue number in PDB)	S34 T38 K180 L184 D193 R195 M196 V197 L198 V199 N200 A201 V202 Y203 F204 K205 G206 W208 Y258 K335 A338 F340 N347 D348 L349 F350 L351 S352 E353 V354 F355 H356 Q357 A358 M359 V360 D361 N363 F408
Binding residue (residue number reindexed from 1)	S33 T37 K139 L143 D152 R154 M155 V156 L157 V158 N159 A160 V161 Y162 F163 K164 G165 W167 Y213 K287 A290 F292 N299 D300 L301 F302 L303 S304 E305 V306 F307 H308 Q309 A310 M311 V312 D313 N315 F350

Enzyme Commision number

	Molecular Function
GO:0004867	serine-type endopeptidase inhibitor activity

	Biological Process
GO:0010466	negative regulation of peptidase activity
GO:0042730	fibrinolysis
GO:0043066	negative regulation of apoptotic process

	Cellular Component
GO:0001533	cornified envelope
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane

PDB	RCSB:1jrr, PDBe:1jrr, PDBj:1jrr
PDBsum	1jrr
PubMed	11546761
UniProt	P05120\|PAI2_HUMAN Plasminogen activator inhibitor 2 (Gene Name=SERPINB2)

[Back to BioLiP]

Structure of PDB 1jrr Chain A Binding Site BS01