Structure of PDB 1jky Chain A Binding Site BS01

Receptor Information
>1jky Chain A (length=748) Species: 1392 (Bacillus anthracis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIG
GKIYIVDGDITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPV
LVIQSSEDYVENTEKALNVYYEIGKILSRDILSKINQPYQKFLDVLNTIK
NASDSDGQDLLFTNQLKEHPTDFSVEFLEQNSNEVQEVFAKAFAYYIEPQ
HRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLSRYEKWEKIKQHY
QHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSD
FLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKK
LKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIG
STLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYS
ISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLE
IKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPK
YTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGR
FVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELR
NDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSY
GRTNEAEFFAEAFRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1jky Crystal structure of the anthrax lethal factor.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		D328 F329 S331 K377 Q384
Binding residue
(residue number reindexed from 1)		D300 F301 S303 K349 Q356
Enzymatic activity
Catalytic site (original residue number in PDB) H686 E687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H658 E659 H662 Y700 E707
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0006508 proteolysis
GO:0035821 modulation of process of another organism
Cellular Component
GO:0005576 extracellular region
GO:0030430 host cell cytoplasm
GO:0044164 host cell cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jky, PDBe:1jky, PDBj:1jky
PDBsum1jky
PubMed11700563
UniProtP15917|LEF_BACAN Lethal factor (Gene Name=lef)

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