Structure of PDB 1jk0 Chain A Binding Site BS01

Receptor Information
>1jk0 Chain A (length=334) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LNKELETLREENRVKSDMLKEKLSKDAENHKAYLKSHQVHRHKLKEMEKE
EPLLNEDKERTVLFPIKYHEIWQAYKRAEASFWTAEEIDLSKDIHDWNNR
MNENERFFISRVLAFFAASDGIVNENLVENFSTEVQIPEAKSFYGFQIMI
ENIHSETYSLLIDTYIKDPKESEFLFNAIHTIPEIGEKAEWALRWIQDAD
ALFGERLVAFASIEGVFFSGSFASIFWLKKRGMMPGLTFSNELICRDEGL
HTDFACLLFAHLKNKPDPAIVEKIVTEAVEIEQRYFLDALPVALLGMNAD
LMNQYVEFVADRLLVAFGNKKYYKVENPFDFMEN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1jk0 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1jk0 Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E176 E239 E273 H276
Binding residue
(residue number reindexed from 1)		E151 E214 E248 H251
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y183 D272
Catalytic site (residue number reindexed from 1) Y158 D247
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0060090 molecular adaptor activity
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jk0, PDBe:1jk0, PDBj:1jk0
PDBsum1jk0
PubMed11526233
UniProtP09938|RIR2_YEAST Ribonucleoside-diphosphate reductase small chain 1 (Gene Name=RNR2)

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