Structure of PDB 1jjw Chain A Binding Site BS01

Receptor Information

>1jjw Chain A (length=173) Species: 727 (Haemophilus influenzae)

TTIVSVRRNGQVVVGGDGQVSLGNTVMKGNARKVRRLYNGKVLAGFAGGT
ADAFTLFELFERKLEMHQGHLLKSAVELAKDWRTDRALRKLEAMLIVADE
KESLIITGIGDVVQPEEDQILAIGSGGNYALSAARALVENTELSAHEIVE
KSLRIAGDICVFTNTNFTIEELP

Ligand information

• Ligand ID: K
• InChI: InChI=1S/K/q+1
• InChIKey: NPYPAHLBTDXSSS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [K+]
• Formula: K
• Name: POTASSIUM ION
• ChEMBL: CHEMBL1233793
• DrugBank: DB01345
• PDB chain: 1jjw Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1jjw Structure of Haemophilus influenzae HslV protein at 1.9 A resolution, revealing a cation-binding site near the catalytic site.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): G157 D158 C160 V161 T163 N164
• Binding residue (residue number reindexed from 1): G157 D158 C160 V161 T163 N164
• Annotation score: 3

Enzymatic activity

• Catalytic site (original residue number in PDB): T1 K33 G45 S125
• Catalytic site (residue number reindexed from 1): T1 K33 G45 S125
• Enzyme Commision number: 3.4.25.2: HslU--HslV peptidase.

Gene Ontology

Molecular Function

• GO:0004298 threonine-type endopeptidase activity
• GO:0005515 protein binding
• GO:0008233 peptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0030163 protein catabolic process
• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005839 proteasome core complex
• GO:0009376 HslUV protease complex

External links

• PDB: RCSB:1jjw, PDBe:1jjw, PDBj:1jjw
• PDBsum: 1jjw
• PubMed: 11717526
• UniProt: P43772|HSLV_HAEIN ATP-dependent protease subunit HslV (Gene Name=hslV)