Structure of PDB 1jdp Chain A Binding Site BS01

Receptor Information

>1jdp Chain A (length=396) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGRLLPPGTRFQ
VAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHW
DLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRA
ALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRN
IQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDG
SWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNM
EDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGI
AGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRP

Ligand information

>1jdp Chain H (length=18) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GCFGLKLDRIGSMSGLGC

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1jdp Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	Y93 G118 E125 Y159 Y169 F170 E173 H176 E177 Q180 I188
Binding residue (residue number reindexed from 1)	Y88 G113 E120 Y154 Y164 F165 E168 H171 E172 Q175 I183

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Cellular Component
GO:0016020	membrane

View graph for
Cellular Component

External links

PDB	RCSB:1jdp, PDBe:1jdp, PDBj:1jdp
PDBsum	1jdp
PubMed	11533490
UniProt	P17342\|ANPRC_HUMAN Atrial natriuretic peptide receptor 3 (Gene Name=NPR3)

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