Structure of PDB 1jb7 Chain A Binding Site BS01

Receptor Information

>1jb7 Chain A (length=460) Species: 200597 (Sterkiella nova)

YEYVELAKASLTSAQPQHFYAVVIDATFPYKTNQERYICSLKIVDPTLYL
KQQKGAGDASDYATLVLYAKRFEDLPIIHRAGDIIRVHRATLRLYNGQRQ
FNANVFYSSSWALFSTDKRSVTQEINNQDAVSDTTPFSFSSKHATIEKNE
ISILQNLRKWANQYFSSYSVISSDMYTALNKAQAQKGDFDVVAKILQVHE
LDEYTNELKLKDASGQVFYTLSLKLKFPHVRTGEVVRIRSATYDETSTQK
KVLILSHYSNIITFIQSSKLAKELRAKIQDDHSVEVASLKKNVSLNAVVL
TEVDKKHAALPSTSLQDLFHHADSDKELQAQDTFRTQFYVTKIEPSDVKE
WVKGYDRKTKKSSSLKGASGKGDNIFQVQFLVKDASTQLNNNTYRVLLYT
QDGLGANFFNVKADNLHKNADARKKLEDSAELLTKFNSYVDAVVERRNGF
YLIKDTKLIY

Ligand information

>1jb7 Chain D (length=12)

ggggttttgggg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1jb7 DNA G-quartets in a 1.86 A resolution structure of an Oxytricha nova telomeric protein-DNA complex.
• Resolution: 1.86 Å
• Binding residue (original residue number in PDB): F63 Y65 K66 Y72 S75 K77 V101 F107 I112 Y130 Q135 D223 D225 Y239 L260 K261 R274 S275 S291 H292 Y293
• Binding residue (residue number reindexed from 1): F28 Y30 K31 Y37 S40 K42 V66 F72 I77 Y95 Q100 D188 D190 Y204 L225 K226 R239 S240 S256 H257 Y258

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0010521 telomerase inhibitor activity
• GO:0043047 single-stranded telomeric DNA binding
• GO:0098505 G-rich strand telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0016233 telomere capping
• GO:0032210 regulation of telomere maintenance via telomerase

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0000782 telomere cap complex
• GO:0000783 nuclear telomere cap complex
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1jb7, PDBe:1jb7, PDBj:1jb7
• PDBsum: 1jb7
• PubMed: 11428895
• UniProt: P29549|TEBA_STENO Telomere-binding protein subunit alpha (Gene Name=MAC-56A)