Structure of PDB 1j5k Chain A Binding Site BS01

Receptor Information

>1j5k Chain A (length=76) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPLEGSEDR
IITITGTQDQIQNAQYLLQNSVKQYS

Ligand information

>1j5k Chain B (length=5) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tccct

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1j5k Molecular basis of sequence-specific single-stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single-stranded DNA.
Resolution	N/A
Binding residue (original residue number in PDB)	A25 G26 S27 I29 G30 K31 G32 G33 R40 I47 K48 I49 R59
Binding residue (residue number reindexed from 1)	A16 G17 S18 I20 G21 K22 G23 G24 R31 I38 K39 I40 R50
Binding affinity	PDBbind-CN: Kd=3uM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

View graph for
Molecular Function

External links

PDB	RCSB:1j5k, PDBe:1j5k, PDBj:1j5k
PDBsum	1j5k
PubMed	12093748
UniProt	P61978\|HNRPK_HUMAN Heterogeneous nuclear ribonucleoprotein K (Gene Name=HNRNPK)

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