Structure of PDB 1j1u Chain A Binding Site BS01

Receptor Information
>1j1u Chain A (length=299) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDEFEMIKRNTSEIISEEELREVLKKDEKSAYIGFEPSGKIHLGHYLQIK
KMIDLQNAGFDIIILLADLHAYLNQKGELDEIRKIGDYNKKVFEAMGLKA
KYVYGSEFQLDKDYTLNVYRLALKTTLKRARRSMELIAREDENPKVAEVI
YPIMQVNDIHYLGVDVAVGGMEQRKIHMLARELLPKKVVCIHNPVLTGLD
GEGNFIAVDDSPEEIRAKIKKAYCPAGVVEGNPIMEIAKYFLEYPLTIKR
PEKFGGDLTVNSYEELESLFKNKELHPMDLKNAVAEELIKILEPIRKRL
Ligand information
>1j1u Chain B (length=74) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccggcgguaguucagccugguagaacggcggacuguagauccgcaugucg
cugguucaaauccggcccgccgga
<<<<<<<..<<<<.........>>>><<<<<<.......>>>>>.>...<
<<<<.......>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB1j1u Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion
Resolution1.95 Å
Binding residue
(original residue number in PDB)		N143 K227 K228 A229 Y230 C231 P232 F261 H283 P284 M285 D286 K288
Binding residue
(residue number reindexed from 1)		N143 K220 K221 A222 Y223 C224 P225 F254 H276 P277 M278 D279 K281
Enzymatic activity
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1j1u, PDBe:1j1u, PDBj:1j1u
PDBsum1j1u
PubMed12754495
UniProtQ57834|SYY_METJA Tyrosine--tRNA ligase (Gene Name=tyrS)

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