Structure of PDB 1im5 Chain A Binding Site BS01

Receptor Information

>1im5 Chain A (length=179) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PEEALIVVDMQRDFMPGGALPVPEGDKIIPKVNEYIRKFKEKGALIVATR
DWHPENHISFRERGGPWPRHCVQNTPGAEFVVDLPEDAVIISKATEPDKE
AYSGFEGTDLAKILRGNGVKRVYICGVATEYCVRATALDALKHGFEVYLL
RDAVKGIKPEDEERALEEMKSRGIKIVQF

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1im5 Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1im5 Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii.
Resolution	1.65 Å
Binding residue (original residue number in PDB)	D52 H54 H71
Binding residue (residue number reindexed from 1)	D51 H53 H70
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	D10 D52 H54 S60 H71 K94 E101 A129 C133
Catalytic site (residue number reindexed from 1)	D9 D51 H53 S59 H70 K93 E100 A128 C132
Enzyme Commision number	3.5.1.19: nicotinamidase.

Gene Ontology

	Molecular Function
GO:0016787	hydrolase activity
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0046872	metal ion binding

	Biological Process
GO:0019363	pyridine nucleotide biosynthetic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:1im5, PDBe:1im5, PDBj:1im5
PDBsum	1im5
PubMed	11714269
UniProt	O58727

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