Structure of PDB 1iiu Chain A Binding Site BS01

Receptor Information
>1iiu Chain A (length=174) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDCRVSSFKVKENFDKNRYSGTWYAMAKKDPEGLFLQDNVVAQFTVDENG
QMSATAKGRVRLFNNWDVCADMIGSFTDTEDPAKFKMKYWGVASFLQKGN
DDHWVVDTDYDTYALHYSCRELNEDGTCADSYSFVFSRDPKGLPPEAQKI
VRQRQIDLCLDRKYRVIVHNGFCS
Ligand information
Ligand IDRTL
InChIInChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
InChIKeyFPIPGXGPPPQFEQ-OVSJKPMPSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CC(=CCO)C=CC=C(C)C=CC1=C(C)CCCC1(C)C
ACDLabs 12.01C1(CCCC(=C1\C=C\C(=C\C=C\C(=C\CO)C)C)C)(C)C
OpenEye OEToolkits 2.0.7CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C
OpenEye OEToolkits 2.0.7CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCO)C)C
CACTVS 3.385CC(=C\CO)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C
FormulaC20 H30 O
NameRETINOL
ChEMBLCHEMBL986
DrugBankDB00162
ZINCZINC000003831417
PDB chain1iiu Chain A Residue 176 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1iiu Structure of Chicken plasma retinol-binding protein
Resolution2.5 Å
Binding residue
(original residue number in PDB)		L35 F36 Y90 L97 Q98
Binding residue
(residue number reindexed from 1)		L34 F35 Y89 L96 Q97
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
GO:0005501 retinoid binding
GO:0005515 protein binding
GO:0016918 retinal binding
GO:0019841 retinol binding
GO:0019904 protein domain specific binding
GO:0034632 retinol transmembrane transporter activity
Biological Process
GO:0001555 oocyte growth
GO:0001654 eye development
GO:0006094 gluconeogenesis
GO:0009615 response to virus
GO:0030277 maintenance of gastrointestinal epithelium
GO:0032024 positive regulation of insulin secretion
GO:0032526 response to retinoic acid
GO:0033189 response to vitamin A
GO:0034633 retinol transport
GO:0042572 retinol metabolic process
GO:0042593 glucose homeostasis
GO:0043627 response to estrogen
GO:0065003 protein-containing complex assembly
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0030136 clathrin-coated vesicle
GO:0060417 yolk
GO:0060418 yolk plasma
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1iiu, PDBe:1iiu, PDBj:1iiu
PDBsum1iiu
PubMed11738088
UniProtP41263|RET4_CHICK Retinol-binding protein 4 (Gene Name=RBP4)

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