Structure of PDB 1ibc Chain A Binding Site BS01

Receptor Information
>1ibc Chain A (length=167) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDST
FLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI
IIQACRGDSPGVVWFKD
Ligand information
Receptor-Ligand Complex Structure
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PDB1ibc A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).
Resolution2.73 Å
Binding residue
(original residue number in PDB)		R179 H237 Q283 C285
Binding residue
(residue number reindexed from 1)		R49 H107 Q153 C155
Enzymatic activity
Catalytic site (original residue number in PDB) P177 R178 H237 G238 C285 R286
Catalytic site (residue number reindexed from 1) P47 R48 H107 G108 C155 R156
Enzyme Commision number 3.4.22.36: caspase-1.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ibc, PDBe:1ibc, PDBj:1ibc
PDBsum1ibc
PubMed9190289
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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