Structure of PDB 1i4a Chain A Binding Site BS01

Receptor Information
>1i4a Chain A (length=309) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASGFNAAEDAQTLRKAMKGLGTDEDAIINVLAYRSTAQRQEIRTAYKTTI
GRDLMDDLKSELSGNFEQVILGMMTPTVLYDVQELRKAMKGAGTDEGCLI
EILASRTPEEIRRINQTYQLQYGRSLEDDIRSDTSFMFQRVLVSLSAGGR
DESNYLDDALMRQDAQDLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFD
EYKRIAQKDIEQSIKSETSGSFEDALLAIVKCMRNKSAYFAERLYKSMKG
LGTDDDTLIRVMVSRAEIDMLDIRANFKRLYGKSLYSFIKGDTSGDYRKV
LLILCGGDD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1i4a Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1i4a Phosphorylation mutants elucidate the mechanism of annexin IV-mediated membrane aggregation.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		M26 G28 G30 E70
Binding residue
(residue number reindexed from 1)		M17 G19 G21 E61
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008201 heparin binding
GO:0030246 carbohydrate binding
GO:0035374 chondroitin sulfate binding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0042584 chromaffin granule membrane
GO:0042589 zymogen granule membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1i4a, PDBe:1i4a, PDBj:1i4a
PDBsum1i4a
PubMed11300800
UniProtP13214|ANXA4_BOVIN Annexin A4 (Gene Name=ANXA4)

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