Structure of PDB 1hy7 Chain A Binding Site BS01

Receptor Information
>1hy7 Chain A (length=162) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTF
SRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDD
DEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLLTRFRLSQDD
INGIQSLYGPPP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1hy7 Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1hy7 Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		H201 H205 H211
Binding residue
(residue number reindexed from 1)		H119 H123 H129
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H201 H205 H211
Catalytic site (residue number reindexed from 1) H119 H123 H129
Enzyme Commision number 3.4.24.17: stromelysin 1.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hy7, PDBe:1hy7, PDBj:1hy7
PDBsum1hy7
PubMed11297453
UniProtP08254|MMP3_HUMAN Stromelysin-1 (Gene Name=MMP3)

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