Structure of PDB 1hxq Chain A Binding Site BS01
Receptor Information
>1hxq Chain A (length=340) Species:
562
(Escherichia coli) [
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TQFNPVDHPHRRYNPLTGQWILVSPHRAKRPWQGAVLPAHDPDCFLCAGN
VRVTGDKNPDYTGTYVFTNDFAALMSDTPDAPESHDPLMRCQSARGTSRV
ICFSPDHSKTLPELSVAALTEIVKTWQEQTAELGKTYPWVQVFENKGAAM
GCSNPHPHGQIWANSFLPNEAEREDRLQKEYFAEQKSPMLVDYVQRELAD
GSRTVVETEHWLAVVPYWAAWPFETLLLPKAHVLRITDLTDAQRSDLALA
LKKLTSRYDNLFQCSFPYSMGWHGAPFNGEENQHWQLHAHFYPPLLRSAT
VRKFMVGYEMLAETQRDLTAEQAAERLRAVSDIHFRESGV
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
1hxq Chain A Residue 350 [
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Receptor-Ligand Complex Structure
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PDB
1hxq
The structure of nucleotidylated histidine-166 of galactose-1-phosphate uridylyltransferase provides insight into phosphoryl group transfer.
Resolution
1.86 Å
Binding residue
(original residue number in PDB)
C52 C55 H115 H164
Binding residue
(residue number reindexed from 1)
C44 C47 H107 H156
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
C52 C55 H115 N153 S161 H164 H166 Q168
Catalytic site (residue number reindexed from 1)
C44 C47 H107 N145 S153 H156 H158 Q160
Enzyme Commision number
2.7.7.12
: UDP-glucose--hexose-1-phosphate uridylyltransferase.
Gene Ontology
Molecular Function
GO:0004335
galactokinase activity
GO:0008108
UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0008198
ferrous iron binding
GO:0008270
zinc ion binding
GO:0016779
nucleotidyltransferase activity
GO:0046872
metal ion binding
Biological Process
GO:0006012
galactose metabolic process
GO:0033499
galactose catabolic process via UDP-galactose
GO:0046835
carbohydrate phosphorylation
Cellular Component
GO:0005737
cytoplasm
GO:0005829
cytosol
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1hxq
,
PDBe:1hxq
,
PDBj:1hxq
PDBsum
1hxq
PubMed
8794735
UniProt
P09148
|GAL7_ECOLI Galactose-1-phosphate uridylyltransferase (Gene Name=galT)
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