Structure of PDB 1hqd Chain A Binding Site BS01

Receptor Information
>1hqd Chain A (length=320) Species: 292 (Burkholderia cepacia) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADNYAATRYPIILVHGLTGTDKYAGVLEYWYGIQEDLQQRGATVYVANLS
GFQSDDGPNGRGEQLLAYVKTVLAATGATKVNLVGHSQGGLTSRYVAAVA
PDLVASVTTIGTPHRGSEFADFVQGVLAYDPTGLSSTVIAAFVNVFGILT
SSSNNTNQDALAALKTLTTAQAATYNQNYPSAGLGAPGSCQTGAPTETVG
GNTHLLYSWAGTAIQPTISVFGVTGATDTSTIPLVDPANALDPSTLALFG
TGTVMVNRGSGQNDGVVSKCSALYGQVLSTSYKWNHLDEINQLLGVRGAN
AEDPVAVIRTHANRLKLAGV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1hqd Chain A Residue 613 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1hqd Complex of Burkholderia cepacia lipase with transition state analogue of 1-phenoxy-2-acetoxybutane: biocatalytic, structural and modelling study.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D242 D288 Q292 V296
Binding residue
(residue number reindexed from 1)		D242 D288 Q292 V296
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) L17 S87 Q88 D242 D264 H286 D288 Q292 V296
Catalytic site (residue number reindexed from 1) L17 S87 Q88 D242 D264 H286 D288 Q292 V296
Enzyme Commision number 3.1.1.3: triacylglycerol lipase.
Gene Ontology
Molecular Function
GO:0004806 triacylglycerol lipase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hqd, PDBe:1hqd, PDBj:1hqd
PDBsum1hqd
PubMed11453990
UniProtP22088|LIP_BURCE Triacylglycerol lipase (Gene Name=lip)

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