Structure of PDB 1hoz Chain A Binding Site BS01

Receptor Information

>1hoz Chain A (length=316) Species: 5699 (Trypanosoma vivax)

GSAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNV
TGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIP
ENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDK
YGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFG
CPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMYYAWD
ALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNP
EAEFFLDMLLRSARAC

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1hoz Chain A Residue 328

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1hoz Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.
• Resolution: 1.6 Å
• Binding residue (original residue number in PDB): D10 D15 T137 D261
• Binding residue (residue number reindexed from 1): D11 D16 T138 D250
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D10 D15 D40 W83 T137 W185 N186 W260 D261
• Catalytic site (residue number reindexed from 1): D11 D16 D41 W84 T138 W186 N187 W249 D250
• Enzyme Commision number: 3.2.2.1: purine nucleosidase.

Gene Ontology

Molecular Function

• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
• GO:0046872 metal ion binding

Biological Process

• GO:0006139 nucleobase-containing compound metabolic process

External links

• PDB: RCSB:1hoz, PDBe:1hoz, PDBj:1hoz
• PDBsum: 1hoz
• PubMed: 11292348
• UniProt: Q9GPQ4