Structure of PDB 1hnl Chain A Binding Site BS01
Receptor Information
>1hnl Chain A (length=130) Species:
9606
(Homo sapiens) [
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KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDR
STDYGIFQINSRYWCNDGKTPGAVNAAHLSCSALLQDNIADAVACAKRVV
RDPQGIRAWVAWRNRCQNRDVRQYVQGCGV
Ligand information
Ligand ID
GSH
InChI
InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
InChIKey
RWSXRVCMGQZWBV-WDSKDSINSA-N
SMILES
Software
SMILES
ACDLabs 12.01
O=C(NCC(=O)O)C(NC(=O)CCC(C(=O)O)N)CS
OpenEye OEToolkits 1.7.6
C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370
N[CH](CCC(=O)N[CH](CS)C(=O)NCC(O)=O)C(O)=O
CACTVS 3.370
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
OpenEye OEToolkits 1.7.6
C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N
Formula
C10 H17 N3 O6 S
Name
GLUTATHIONE
ChEMBL
CHEMBL1543
DrugBank
DB00143
ZINC
ZINC000003830891
PDB chain
1hnl Chain A Residue 500 [
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Receptor-Ligand Complex Structure
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PDB
1hnl
Structure of a glutathionylated human lysozyme: a folding intermediate mimic in the formation of a disulfide bond.
Resolution
1.8 Å
Binding residue
(original residue number in PDB)
Y63 W64 A77 L79 C95 R98
Binding residue
(residue number reindexed from 1)
Y63 W64 A77 L79 C95 R98
Annotation score
4
Enzymatic activity
Catalytic site (original residue number in PDB)
E35 N46 D49 S51 D53 N60
Catalytic site (residue number reindexed from 1)
E35 N46 D49 S51 D53 N60
Enzyme Commision number
3.2.1.17
: lysozyme.
Gene Ontology
Molecular Function
GO:0003796
lysozyme activity
GO:0016798
hydrolase activity, acting on glycosyl bonds
GO:0042802
identical protein binding
Biological Process
GO:0006954
inflammatory response
GO:0019730
antimicrobial humoral response
GO:0031640
killing of cells of another organism
GO:0042742
defense response to bacterium
GO:0050829
defense response to Gram-negative bacterium
GO:0050830
defense response to Gram-positive bacterium
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
GO:0035578
azurophil granule lumen
GO:0035580
specific granule lumen
GO:0070062
extracellular exosome
GO:1904724
tertiary granule lumen
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1hnl
,
PDBe:1hnl
,
PDBj:1hnl
PDBsum
1hnl
PubMed
15299791
UniProt
P61626
|LYSC_HUMAN Lysozyme C (Gene Name=LYZ)
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