Structure of PDB 1hl3 Chain A Binding Site BS01

Receptor Information
>1hl3 Chain A (length=331) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALM
YHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASV
EETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAARIRGE
TLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQD
LLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKAL
AQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASI
EMREEAAREIRRAITGRIPDSLKNCVNKDHL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1hl3 Ctbp/Bars: A Dual-Function Protein Involved in Transcription Co-Repression and Golgi Membrane Fission
Resolution3.1 Å
Binding residue
(original residue number in PDB)		M31 V40 A41 F42 C43 E50 H52 E53 L345
Binding residue
(residue number reindexed from 1)		M17 V26 A27 F28 C29 E36 H38 E39 L331
Enzymatic activity
Catalytic site (original residue number in PDB) S113 R255 D279 E284 H304
Catalytic site (residue number reindexed from 1) S99 R241 D265 E270 H290
Enzyme Commision number 1.1.1.-
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:1hl3, PDBe:1hl3, PDBj:1hl3
PDBsum1hl3
PubMed12805226
UniProtQ9Z2F5|CTBP1_RAT C-terminal-binding protein 1 (Gene Name=Ctbp1)

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