Structure of PDB 1hdk Chain A Binding Site BS01

Receptor Information
>1hdk Chain A (length=139) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLLPVPYTEAASLSTGSTVTIKGRPLVCFLNEPYLQVDFHTEMKEESDIV
FHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQ
VMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYL
Ligand information
Ligand IDPMB
InChIInChI=1S/C6H5O3S.Hg/c7-10(8,9)6-4-2-1-3-5-6;/h2-5H,(H,7,8,9);
InChIKeyKQAOIKIZSJJTII-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1cc(ccc1S(=O)(=O)O)[Hg]
CACTVS 3.341O[S](=O)(=O)c1ccc([Hg])cc1
ACDLabs 10.04[Hg]c1ccc(cc1)S(=O)(=O)O
FormulaC6 H5 Hg O3 S
NamePARA-MERCURY-BENZENESULFONIC ACID
ChEMBL
DrugBankDB02983
ZINC
PDB chain1hdk Chain A Residue 929 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1hdk Charcot-Leyden Crystal Protein (Galectin-10) is not a Dual Function Galectin with Lysophospholipase Activity But Binds a Lysophospholipase Inhibitor in a Novel Structural Fashion.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C29 D85
Binding residue
(residue number reindexed from 1)		C28 D84
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.1.5: lysophospholipase.
Gene Ontology
Molecular Function
GO:0004622 lysophospholipase activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042802 identical protein binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
GO:0002667 regulation of T cell anergy
GO:0002724 regulation of T cell cytokine production
GO:0046006 regulation of activated T cell proliferation
GO:0070231 T cell apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0062023 collagen-containing extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hdk, PDBe:1hdk, PDBj:1hdk
PDBsum1hdk
PubMed11834744
UniProtQ05315|LEG10_HUMAN Galectin-10 (Gene Name=CLC)

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