Structure of PDB 1h7r Chain A Binding Site BS01

Receptor Information
>1h7r Chain A (length=342) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MHTAEFLETEPTEISSVLAGGYNHPLLRQWQSERQLTKNMLIFPLFISDN
PDDFTEIDSLPNINRIGVNRLKDYLKPLVAKGLRSVILFGVPLIPGTKDP
VGTAADDPAGPVIQGIKFIREYFPELYIICDVCLCEYTSHGHCGVLYDDG
TINRERSVSRLAAVAVNYAKAGAHCVAPSDMIDGRIRDIKRGLINANLAH
KTFVLSYAAKFSGNLYGPFRDAACSAPSNGDRKCYQLPPAGRGLARRALE
RDMSEGADGIIVKPSTFYLDIMRDASEICKDLPICAYHVSGEYAMLHAAA
EKGVVDLKTIAFESHQGFLRAGARLIITYLAPEFLDWLDEEN
Ligand information
Ligand IDSHU
InChIInChI=1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11)
InChIKeyWYEPBHZLDUPIOD-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CC(=O)CC(=O)CCC(O)=O
OpenEye OEToolkits 1.5.0CC(=O)CC(=O)CCC(=O)O
ACDLabs 10.04O=C(CC(=O)C)CCC(=O)O
FormulaC7 H10 O4
Name4,6-DIOXOHEPTANOIC ACID;
SUCCINYLACETONE
ChEMBLCHEMBL222824
DrugBank
ZINCZINC000100036983
PDB chain1h7r Chain A Residue 1343 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1h7r The X-Ray Structure of Yeast 5-Aminolaevulinic Acid Dehydratase Complexed with Substrate and Three Inhibitors
Resolution2.0 Å
Binding residue
(original residue number in PDB)		D131 S179 K210 Y216 F219 K263 Y287 V289 S290 Y329
Binding residue
(residue number reindexed from 1)		D131 S179 K210 Y216 F219 K263 Y287 V289 S290 Y329
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) K210 K263
Catalytic site (residue number reindexed from 1) K210 K263
Enzyme Commision number 4.2.1.24: porphobilinogen synthase.
Gene Ontology
Molecular Function
GO:0004655 porphobilinogen synthase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1h7r, PDBe:1h7r, PDBj:1h7r
PDBsum1h7r
PubMed11545591
UniProtP05373|HEM2_YEAST Delta-aminolevulinic acid dehydratase (Gene Name=HEM2)

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