Structure of PDB 1h4p Chain A Binding Site BS01

Receptor Information
>1h4p Chain A (length=408) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YYDYDHGSLGEPIRGVNIGGWLLLEPYITPSLFEAFRTNDDNDEGIPVDE
YHFCQYLGKDLAKSRLQSHWSTFYQEQDFANIASQGFNLVRIPIGYWAFQ
ILDDDPYVSGLQESYLDQAIGWARNNSLKVWVDLHGAAGSQNGFDNSGLR
DSYKFLEDSNLAVTINVLNYILKKYSAEEYLDIVIGIELINEPLGPVLDM
DKMKNDYLAPAYEYLRNNIKSDQVIIIHDAFQPYNYWDDFMTENDGYWGV
TIDHHHYQVFASDQLERSIDEHIKVACEWGTGVLNESHWIVCGEFAAALT
DCIKWLNSVGFGARYDGSWVNGDQTSSYIGSCANNDDIAYWSDERKENTR
RYVEAQLDAFEMRGGWIIWCYKTESSLEWDAQRLMFNGLFPQPLTDRKYP
NQCGTISN
Ligand information
Ligand IDBMA
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-RWOPYEJCSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-mannopyranose;
beta-D-mannose;
D-mannose;
mannose
ChEMBL
DrugBank
ZINCZINC000003830679
PDB chain1h4p Chain D Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1h4p The Er Protein Folding Sensor Udp-Glucose Glycoprotein:Glucosyltransferase Modifies Substrates Distant to Local Changes in Glycoprotein Conformation.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		Y276 D279
Binding residue
(residue number reindexed from 1)		Y236 D239
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E232 E334
Catalytic site (residue number reindexed from 1) E192 E294
Enzyme Commision number 3.2.1.58: glucan 1,3-beta-glucosidase.
Gene Ontology
Molecular Function
GO:0004338 glucan exo-1,3-beta-glucosidase activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0005975 carbohydrate metabolic process
GO:0009251 glucan catabolic process
GO:0031505 fungal-type cell wall organization
GO:0044042 glucan metabolic process
GO:0071555 cell wall organization
Cellular Component
GO:0000324 fungal-type vacuole
GO:0005576 extracellular region
GO:0009277 fungal-type cell wall
GO:0009986 cell surface

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1h4p, PDBe:1h4p, PDBj:1h4p
PDBsum1h4p
PubMed14730348
UniProtP23776|EXG1_YEAST Glucan 1,3-beta-glucosidase I/II (Gene Name=EXG1)

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