Structure of PDB 1h3e Chain A Binding Site BS01

Receptor Information
>1h3e Chain A (length=427) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HTPEEALALLKRGAEEIVPEEELLAKLKEGRPLTVKLGADPTRPDLHLGH
AVVLRKMRQFQELGHKVVLIIGDFTGMIGDPSGRSKTRPPLTLEETRENA
KTYVAQAGKILRQEPHLFELRYNSEWLEGLTFKEVVRLTSLMTVAQMLER
EDFKKRYEAGIPISLHELLYPFAQAYDSVAIRADVEMGGTDQRFNLLVGR
EVQRAYGQSPQVCFLMPLLVGLDGREKMSKSLDNYIGLTEPPEAMFKKLM
RVPDPLLPSYFRLLTDLEEEEIEALLKAGPVPAHRVLARLLTAAYALPQI
PPRIDRAFYESLGYAWEAFGRDKEAGPEEVRRAEARYDEVAKGGIPEEIP
EVTIPASELKEGRIWVARLFTLAGLTPSNAEARRLIQNRGLRLDGEVLTD
PMLQVDLSRPRILQRGKDRFVRVRLSD
Ligand information
>1h3e Chain B (length=84) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggcagguucccgagcggccaaaggggacggucuguaaaaccguuggcgu
augccuucgcugguucgaauccagcccugcccac
<<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<..
..>>>...<<<<<.......>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1h3e Class I Tyrosyl-tRNA Synthetase Has a Class II Mode or tRNA Recognition
Resolution2.9 Å
Binding residue
(original residue number in PDB)		G165 P167 R256 D259 V286 Y342 V345 A346 K365 W370 R373 S383 N384 A385 R389 N393 R394 G395 Q409 R420 G421 K422 D423
Binding residue
(residue number reindexed from 1)		G160 P162 R251 D254 V281 Y337 V340 A341 K360 W365 R368 S378 N379 A380 R384 N388 R389 G390 Q404 R415 G416 K417 D418
Enzymatic activity
Catalytic site (original residue number in PDB) T47 H52 H55 R89 R93 Q179 D196 K232 K235 S236
Catalytic site (residue number reindexed from 1) T42 H47 H50 R84 R88 Q174 D191 K227 K230 S231
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1h3e, PDBe:1h3e, PDBj:1h3e
PDBsum1h3e
PubMed12110594
UniProtP83453|SYY_THET2 Tyrosine--tRNA ligase (Gene Name=tyrS)

[Back to BioLiP]