Structure of PDB 1gww Chain A Binding Site BS01
Receptor Information
>1gww Chain A (length=287) Species:
9913
(Bos taurus) [
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KLKLSDWFNPFKRPEVVTMTKWKAPVVWEGTYNRAVLDNYYAKQKITVGL
TVFAVGRYIEHYLEEFLTSANKHFMVGHPVIFYIMVDDVSRMPLIELGPL
RSFKVFKIKPEKRWQDISMMRMKTIGEHIVAHIQHEVDFLFCMDVDQVFQ
DKFGVETLGESVAQLQAWWYKADPNDFTYERRKESAAYIPFGEGDFYYHA
AIFGGTPTQVLNITQECFKGILKDKKNDIEAQWHDESHLNKYFLLNKPTK
ILSPEYCWDYHIGLPADIKLVKMSWQTKEYNVVRNNV
Ligand information
Ligand ID
UDP
InChI
InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKey
XCCTYIAWTASOJW-XVFCMESISA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.7.0
C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.370
O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.370
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.0
C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
ACDLabs 12.01
O=P(O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
Formula
C9 H14 N2 O12 P2
Name
URIDINE-5'-DIPHOSPHATE
ChEMBL
CHEMBL130266
DrugBank
DB03435
ZINC
ZINC000004490939
PDB chain
1gww Chain A Residue 1369 [
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Receptor-Ligand Complex Structure
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PDB
1gww
Structural Basis of Ordered Binding of Donor and Acceptor Substrates to the Retaining Glycosyltransferase, Alpha -1,3 Galactosyltransferase
Resolution
1.8 Å
Binding residue
(original residue number in PDB)
F134 A135 V136 Y139 I198 R202 D225 V226 D227 K359 Y361 R365
Binding residue
(residue number reindexed from 1)
F53 A54 V55 Y58 I117 R121 D144 V145 D146 K278 Y280 R284
Annotation score
3
Binding affinity
PDBbind-CN
: -logKd/Ki=3.59,Kd=0.258mM
Enzymatic activity
Catalytic site (original residue number in PDB)
Q247 H280 W314 E317 W356 R365
Catalytic site (residue number reindexed from 1)
Q166 H199 W233 E236 W275 R284
Enzyme Commision number
2.4.1.87
: N-acetyllactosaminide 3-alpha-galactosyltransferase.
Gene Ontology
Molecular Function
GO:0016758
hexosyltransferase activity
Biological Process
GO:0005975
carbohydrate metabolic process
Cellular Component
GO:0016020
membrane
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1gww
,
PDBe:1gww
,
PDBj:1gww
PDBsum
1gww
PubMed
12011052
UniProt
P14769
|GGTA1_BOVIN N-acetyllactosaminide alpha-1,3-galactosyltransferase (Gene Name=GGTA1)
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